Synthesis and nematicidal activity of piperazinedione derivatives based on the natural product Barettin |
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Authors: | Haiyang Sun Hui Li Jiayi Wang Gonghua Song |
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Institution: | Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China |
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Abstract: | Nematodes are serious constraints of crop production worldwide. However, the traditional nematicides suffer from the side-effects, including environmental and human toxicity. Herein, more than 70 novel piperazinedione derivatives based on the natural product Barettin were synthesized and evaluated against the root-knot nematode Meloidogyne incognita (M. incognita). While most of synthesized compounds exhibited certain nematicidal activity at high concentration, the best one showed a nematicidal activity of 75% at 2.4 μmol/L. |
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Keywords: | 5-HT Barettin Nature product Nematicidal activity Piperazinedione derivatives |
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