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Synthesis of cyclic peptide reniochalistatin E and conformational isomers |
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| Authors: | Huiyun Luo Hongli Yin Chaojun Tang Ping Wang Feng Liang |
| Affiliation: | a The State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China;b Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;c Chonqqing Huapont Pharm. Co., Ltd., Chongqing 401121, China |
| Abstract: | Here, we report a convenient and efficient synthesis strategy for the total synthesis of cyclic peptide reniochalistatin E and its conformational isomers with 32% overall yield. We found the linear peptide precursor without side chain gave better cyclization yield. |
| Keywords: | Cyclic peptide Reniochalistatin E Solid-phase peptide synthgesis Conformational isomers |
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