Highly biocompatible BSA-MnO2 nanoparticles as an efficient near-infrared photothermal agent for cancer therapy |
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| Authors: | Yuzhen Wang Yujun Song Guixian Zhu Dechen Zhang Xuewu Liu |
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| Institution: | a Key Laboratory of Flexible Electronics(KLOFE) & Institute of Advanced Materials(IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials(SICAM), Nanjing Tech University(NanjingTech), Nanjing 211816, China;
b Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China;
c Department of Nanomedicine, Houston Methodist Research Institute, Houston TX 77030, United States |
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| Abstract: | More recently, the biomedical applications of MnO2 in bioanalysis, cell imaging, and drug delivery as a result of their appealing physicochemical properties, have been reported and expanded rapidly. However, research on a near infrared (NIR) photothermal response of MnO2 was ignored. In this work, we reported a facile, one-pot method to synthesis of bovine serum albumin (BSA)-reduced and stabilized MnO2 nanoparticles (BSA-MnO2 NPs) with good aqueous dispersibility and high biocompatibility. And we also showed for the first time that BSA-MnO2 NPs displayed superior NIR photothermal efficiency and photostability which demonstrated as a novel class of photothermal antitumor agent. |
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| Keywords: | Bovine serum albumin Manganese dioxide Photothermal NIR Cancer therapy |
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