Isatindolignanoside A,a glucosidic indole-lignan conjugate from an aqueous extract of the Isatis indigotica roots |
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Authors: | Lingjie Meng Qinglan Guo Minghua Chen Jiandong Jiang Yuhuan Li Jiangong Shi |
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Institution: | State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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Abstract: | A glucosidic indole-lignan conjugate with a novel carbon skeleton, named isatindolignanoside A (1), was isolated from an aqueous extract of the Isatis indigotica roots “ban lan gen”. Its structure was elucidated by comprehensive analysis of spectroscopic data, including J- and NOESY correlation-based configurational analysis, circular dichroism (CD) data, enzyme hydrolysis, and theoretical ECD calculation. In a preliminary assay, compound 1 showed antiviral activity against Coxsackie virus B3. This compound is the first example of natural product having a structural feature of conjugation between indole and lignan units, and its biosynthetic pathway is postulated. |
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Keywords: | Cruciferae Ban lan gen Indole-lignan conjugate Isatindolignanoside A Antiviral activity |
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