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Selective recognition of HIV RNA by dinuclear metallic ligands |
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| Authors: | Xuedong Li Bo Chen Ling Lan Ruili Wang Duqiang Luo Li Liu Liang Cheng |
| Affiliation: | a Beijing National Laboratory for Molecular Sciences(BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;b College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, China;c University of Chinese Academy of Sciences, Beijing 100049, China |
| Abstract: | We describe the development of dinuclear metallic ligands to target specific HIV RNA structures. Two series of dipyridinyl-N bridged dinuclear metal complexes were synthesized in moderate to good yields and their binding activities toward TAR and RRE RNA were studied both experimentally and theoretically. The docking calculation elucidated some structure features in dimetallic complexes that can affect TAR RNA-binding properties. |
| Keywords: | HIV RNA Dinuclear metallic ligands Binding Molecular recognition Selectivity |
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