| Preparation and chromatographic evaluation of a chiral stationary phase based on carboxymethyl-β-cyclodextrin for high-performance liquid chromatography |
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| 作者姓名： | Min Zhou Yuande Long Yonggang Zhi Xiaoying Xu |
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| 作者单位： | a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 640041, China;
b University of Chinese Academy of Sciences, Beijing 100049, China |
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| 摘 要： | A novel chiral stationary phase (CSP) was prepared by chemically bonding carboxymethyl-β-cyclodextrin (CM-β-CD) onto 3-aminopropyl silica gel and showed excellent enantioseparation abilities for a broad range of chiral compounds and drugs.
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| 关 键 词： | Enantioseparation Carboxymethyl-&beta -cyclodextrin Chiral stationary phase Chemical bonding Reversed-phase |
| 收稿时间： | 15 August 2017 |
Preparation and chromatographic evaluation of a chiral stationary phase based on carboxymethyl-β-cyclodextrin for high-performance liquid chromatography |
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| Min Zhou,Yuande Long,Yonggang Zhi,Xiaoying Xu.Preparation and chromatographic evaluation of a chiral stationary phase based on carboxymethyl-β-cyclodextrin for high-performance liquid chromatography[J].Chinese Chemical Letters,2018,29(9):1399-1403. |
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| Authors: | Min Zhou Yuande Long Yonggang Zhi Xiaoying Xu |
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| Institution: | a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 640041, China;
b University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | A chiral stationary phase (CSP) was prepared by chemically bonding carboxymethyl-β-cyclodextrin (CM-β-CD) onto 3-aminopropyl silica gel through amidation reaction in water solution and was characterized by Fourier transform infrared spectroscopy (FT-IR), element analysis (EA) and thermal gravimetry analysis (TGA). The chromatographic performance was evaluated with 24 racemates under reversed-phase conditions. The effect of salt, organic modifier, mobile phase pH and structures of analytes were discussed. In comparison with native β-CD bonded column, CYCLOBOND I 2000, CM-β-CD CSP exhibited enhanced enantioseparation. |
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| Keywords: | Enantioseparation Chiral stationary phase Chemical bonding Reversed-phase |
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