| Rhodium-catalyzed oxidative homologation of N-pyrimidyl indolines with alkynes via dual C—H activation: Facile synthesis of benzo[g] indolines |
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| 引用本文： | Lianhui Wang,Dan Xiong,Lianghua Jie,Chudan Yu,Xiuling Cui. Rhodium-catalyzed oxidative homologation of N-pyrimidyl indolines with alkynes via dual C—H activation: Facile synthesis of benzo[g] indolines[J]. 中国化学快报, 2018, 29(6): 907-910. DOI: 10.1016/j.cclet.2018.05.007 |
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| 作者姓名： | Lianhui Wang Dan Xiong Lianghua Jie Chudan Yu Xiuling Cui |
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| 作者单位： | Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China |
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| 基金项目： | This research was supported by the National Natural Science Foundation of China (Nos. 21602064 and 21572072), the Natural Science Foundation of Fujian Province (No. 2015J01056), and Huaqiao University (No. ZQN-PY317). |
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| 摘 要： | An efficient route to benzo[g]indolines by a rhodium-catalyzed C6- and C7 H functionalization of indolines with alkynes was achieved, which is potentially applicable to the synthesis of benzo[g] indoles through oxidation/removal of the directing group.
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| 收稿时间： | 2018-04-28 |
Rhodium-catalyzed oxidative homologation of N-pyrimidyl indolines with alkynes via dual CH activation: Facile synthesis of benzo[g]indolines |
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| Lianhui Wang,Dan Xiong,Lianghua Jie,Chudan Yu,Xiuling Cui. Rhodium-catalyzed oxidative homologation of N-pyrimidyl indolines with alkynes via dual CH activation: Facile synthesis of benzo[g]indolines[J]. Chinese Chemical Letters, 2018, 29(6): 907-910. DOI: 10.1016/j.cclet.2018.05.007 |
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| Authors: | Lianhui Wang Dan Xiong Lianghua Jie Chudan Yu Xiuling Cui |
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| Affiliation: | Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China |
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| Abstract: | We herein report a highly regioselective rhodium-catalyzed C6- and C7H![/>H bond functionalization of indolines with alkynes by using 2-pyrimidine as a directing group. Moreover, <em>NH</em>-free benzo[<em>g</em>]indole unit could be obtained by an oxidation/removal of the directing group sequence.</td>
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| Keywords: | Rhodium Indoline Alkyne Corresponding author. |
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