Dynamic stability and thermodynamic characterization in an enzymatic reaction at the single molecule level |
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| Authors: | Moisés Santillán |
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| Institution: | 1. Department of Mathematics, Sun Yat-sen University, Guangzhou, 510275, PR China;2. Department of Computer Science, Guangdong Polytechnic Normal University, Guangzhou, 510665, PR China;1. Departamento de Ingeniería Eléctrica-SEES, CINVESTAV-IPN, Mexico;2. Instituto de Energías Renovables (IER-UNAM), Temixco, Mexico;1. Departamento de Matemáticas, Universidad de Murcia, Campus del Espinardo, 30100 Murcia, Spain;2. Centro de Investigación Operativa, Universidad Miguel Hernández de Elche, Avda, Universidad s/n, 03202 Elche (Alicante), Spain |
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| Abstract: | In this work we study, at the single molecular level, the thermodynamic and dynamic characteristics of an enzymatic reaction comprising a rate limiting step. We investigate how the stability of the enzyme-state stationary probability distribution, the reaction velocity, and its efficiency of energy conversion depend on the system parameters. We employ in this study a recently introduced formalism for performing a multiscale thermodynamic analysis in continuous-time discrete-state stochastic systems. |
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