A new fluorescent and colorimetric probe for Cu2+ in live cells |
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Authors: | Liu Wei-Yong Li Hai-Ying Zhao Bao-Xiang Miao Jun-Ying |
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Affiliation: | Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China. |
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Abstract: | Based on a change in structure between spirocyclic (non-fluorescent) and ring-open (fluorescent) forms of rhodamine-based dyes, a new fluorescent and colorimetric Cu(2+) probe was designed and synthesized. Upon treatment with Cu(2+), the weakly fluorescent probe exhibited a strong fluorescence response with high selectivity. In addition, the turn-on fluorescent probe upon the addition of Cu(2+) was applied in live cell imaging. |
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