| 热磁双重响应性载药微囊的制备及其性能研究 |
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| 引用本文： | 容建华,段泰炜,温鸿戈,屈小中.热磁双重响应性载药微囊的制备及其性能研究[J].高分子学报,2010,0(4):484-489. |
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| 作者姓名： | 容建华 段泰炜 温鸿戈 屈小中 |
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| 作者单位： | 1. 暨南大学材料科学与工程系,广州,510632
2. 中国科学院化学研究所,高分子物理与化学国家重点实验室,北京,100190 |
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| 基金项目： | 国家自然科学基金(基金号20604010);;暨南大学“211工程”生物材料与组织工程创新基金(基金号50621030)资助项目 |
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| 摘 要： | 采用LbL模板技术,将天然聚电解质壳聚糖CS和海藻酸钠ALG、磁性纳米颗粒Fe3O4或带负电荷或双亲性磷脂在单分散胶体表面进行组装,制备了一种具有热磁双重响应性的新型载药微囊.通过透射电镜、激光共聚焦显微镜、zeta-电位分析仪、紫外分光光度计等对微囊结构及载药、释药性能进行了表征.实验结果表明:微囊的载药量最高可达到22.40%,且具有磁导向作用.微囊外层组装具有热敏性质的磷脂层能有效地克服壳聚糖/海藻酸钠微囊通透性大而导致在较低温(正常生理环境)的输送过程中药物泄漏问题,而在较高温条件下又可使药物迅速释放,从而实现药物的可控释放.
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| 关 键 词： | 逐层自组装 微囊 磷脂 磁性纳米颗粒 药物缓释 |
| 收稿时间： | 2009-09-25 |
PREPARATION AND CHARATERIZATION OF THE DRUG LOADED MICROCAPSULES WITH THERMO- AND MAGNETIC-SENSITITIES |
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| RONG Jianhua,DUAN Taiwei,WEN Hongge,QU Xiaozhong.PREPARATION AND CHARATERIZATION OF THE DRUG LOADED MICROCAPSULES WITH THERMO- AND MAGNETIC-SENSITITIES[J].Acta Polymerica Sinica,2010,0(4):484-489. |
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| Authors: | RONG Jianhua DUAN Taiwei WEN Hongge QU Xiaozhong |
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| Institution: | 1 Department of Materials Science and Engineering;Jinan University;Guangzhou 510632;2 State Key Laboratory of Polymer Physics and Chemistry;Institute of Chemistry;Chinese Academy of Sciences;Beijing 100190 |
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| Abstract: | A novel targeted carrier of drug loaded microcapsules with thermo- and magnetic-sensitivities was fabricated by the layer-by-layer self-assembly technique. Natural polyelectrolytes such as chitosan and sodium alginate,magnetic nanoparticles Fe3O4,and lipid dipalmitoyl-sn-glycero-3-phosphate ( monosodium salt ) (DPPA),(1,2-dipalmitoyl-sn-glycero-3-phosphocholine) (DPPC) or their composite 10% DPPA/90% DPPC were used as components of microcapsule. The structure,drug loading and thermo-sensitive drug release o... |
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| Keywords: | Microcapsule Drug delivery Magnetic nanoparticle Lipid Thermo-sensitivity |
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