On the use of Laplace's equation for global predictions of internuclear separation and dissociation energy

Properties of target species can be estimated by various means including interpolations in periodic charts. Interpolation is equivalent to numerical solution of the Laplace equation. A test of this equivalence, within some confidence level, for any N-atomic molecule surrounded by 4N nearest neighbors: the sum of the second differences of the data in all directions must be zero. Since very few molecules have 4N neighbors with known data, the test becomes: the sum of the averages of the second differences must be zero. The validity of these tests is explored. For radii of main-group atoms, and for internuclear separations of their diatomic combinations, the averages are different from zero and the sums of the averages are zero to within one if second-nearest neighbors are used. Dissociation potentials pass the tests but with larger scatter. Predictions for dissociation potentials, using iterative interpolation within boundaries on which there are known data, are reviewed.