Enantiospecific synthesis of pseudoacarviosin as a potential antidiabetic agent |
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Authors: | Shing Tony K M Cheng Hau M Wong Wai F Kwong Connie S K Li Jianmei Lau Clara B S Leung Po Sing Cheng Christopher H K |
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Institution: | Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong, China. tonyshing@cuhk.edu.hk |
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Abstract: | A pseudo-1,4'- N-linked disaccharide, pseudoacarviosin 5, was constructed via a key palladium-catalyzed coupling reaction of pseudoglycosyl chloride 8 (prepared from d-glucose via a novel direct intramolecular aldol addition in 12 steps) and pseudo-4-amino-4,6-dideoxy-alpha- d-glucose 9 (prepared from l-arabinose via an unusual trans-fused isoxazolidine-selective intramolecular nitrone-alkene cycloaddition in 11 steps). Pseudoacarviosin 5 has been shown to be a potent inhibitor of alpha-glucosidases, particularly the intestinal mucosal enzymes sucrase and glucoamylase of relevance to blood glucose control. |
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