| 茚磺苯酰胺及其合成中间体的NMR研究 |
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| 引用本文： | 赵成志,徐庆仑. 茚磺苯酰胺及其合成中间体的NMR研究[J]. 高等学校化学学报, 1987, 8(1): 65 |
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| 作者姓名： | 赵成志 徐庆仑 |
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| 作者单位： | 吉林大学理论化学研究所 |
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| 摘 要： | 合成了茚磺苯酰胺(Ⅰ),测试了它的1HNMR谱以及合成中间体(Ⅱ-Ⅶ)的1H和13CNMR谱,常温下观测到了化合物(Ⅲ)的旋转异构现象,讨论了ABX自旋系统中,解析质子化学位移的另一种方法。
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| 收稿时间： | 1985-09-06 |
A Study on Indapamide and Its Synthesizing Intermediates by NMR |
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| Zhao Chengzhi,Xu Qinglun. A Study on Indapamide and Its Synthesizing Intermediates by NMR[J]. Chemical Research In Chinese Universities, 1987, 8(1): 65 |
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| Authors: | Zhao Chengzhi Xu Qinglun |
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| Affiliation: | Institute of Theoretical Chemistry, Jilin University, Changchun |
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| Abstract: | Indapamide (Ⅰ) is a antihypcrtensive drug with high efficacy and long-time activity, which is recommended by many experts worked at international medicine circles. We have synthesized this compound and determined its 1HNMR spectrum. Also, 1H and 13CNMR spectra of intermediates (Ⅱ-Ⅶ), which are formed in the process of synthesis of compound (Ⅰ), are determined. The rotational isomerism of the compound (Ⅲ) was observed at the room temperature. Another analysis method on chemical shifts in ABXspin system was discussed. |
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