Alkaloids from Croton flavens L. and their affinities to GABA-receptors |
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| Authors: | Eisenreich Wolfram J Höfner Georg Bracher Franz |
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| Affiliation: | Department für Pharmazie-Zentrum für Pharmaforschung, Ludwig-Maximilians-Universit?t, Butenandtstr. 5-13, 81377 München, Germany. |
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| Abstract: | Phytochemical investigation of several plants of Croton flavens L. from Barbados has led to the isolation of the tetrahydroprotoberberine alkaloids scoulerine and coreximine, as well as the morphinanedienones salutaridine and its racemic form salutarine, sebiferine, norsinoacutine and flavinantine. In a screening for 3H-GABA displacing activity coreximine showed the highest affinity to the GABA(A) receptor. |
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