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一种可用于检测2,4,6-三硝基苯酚的杂环芳族卤化物小分子荧光探针
引用本文:董子越,周晓霞,赵晓慧,叶达莹,安悦. 一种可用于检测2,4,6-三硝基苯酚的杂环芳族卤化物小分子荧光探针[J]. 应用化学, 2020, 37(3): 332-339. DOI: 10.11944/j.issn.1000-0518.2020.03.190286
作者姓名:董子越  周晓霞  赵晓慧  叶达莹  安悦
作者单位:辽宁师范大学化学化工学院 辽宁 大连 116029
基金项目:辽宁省科技厅自然基金指导计划项目(2019-ZD-0470)资助。
摘    要:以2,6-二甲氧基苯甲酸为起始原料得到氨基噻二唑衍生物,通过Gattermann反应合成一种杂环芳族卤化物2-氯-5-(3-氯-2,6-二甲氧基苯基)-1,3,4-噻二唑(L),利用核磁共振波谱仪(NMR)和高分辨率质谱仪(HRMS)等测试手段确定了结构,并将其用作小分子荧光探针检测2,4,6-三硝基苯酚(TNP),系统地研究了其荧光特性,并且结合理论计算,探究了其可能的猝灭机制。 研究结果表明,探针L对TNP具有高选择性、高灵敏度、抗干扰能力强,在较宽的pH值范围内,仍然表现出良好的荧光性能。 具有较低的检测限(4.2×10-7 mol/L),可用于实际水样中TNP的检测。

关 键 词:杂环芳族卤化物  荧光探针  2  4  6-三硝基苯酚  理论计算  
收稿时间:2019-10-25

A Heterocyclic Aromatic Halide Small Molecule Fluorescent Probe for the Detection of 2,4,6-Trinitrophenol
DONG Ziyue,ZHOU Xiaoxia,ZHAO Xiaohui,YE Daying,AN Yue. A Heterocyclic Aromatic Halide Small Molecule Fluorescent Probe for the Detection of 2,4,6-Trinitrophenol[J]. Chinese Journal of Applied Chemistry, 2020, 37(3): 332-339. DOI: 10.11944/j.issn.1000-0518.2020.03.190286
Authors:DONG Ziyue  ZHOU Xiaoxia  ZHAO Xiaohui  YE Daying  AN Yue
Affiliation:College of Chemistry and Chemical Engineering, Liaoning Normal University,Dalian,Liaoning 116029,China
Abstract:The heterocyclic aromatic halide,2-chloro-5-(3-chloro-2,6-dimethoxyphenyl)-1,3,4-thiadiazole(L),was synthesized by Gattermann reaction from the aminothiadiazole derivative.Its structure was characterized by nuclear magnetic resonance spectroscopy(NMR)and high resolution mass spectrometry(HRMS).Probe L was used as a small molecule fluorescent probe to detect 2,4,6-trinitrophenol(TNP),and its fluorescence characteristics were systematically studied.Furthermore,combined with theoretical calculations,the possible quenching mechanism was explored.The results showed that the probe L had high seletivity,high sensitivity and strong anti-interference ability to TNP,and exhibited good fluorescence performance in a wide pH range.It has lower detection limit(4.2×10^-7 mol/L)and can be used for the detection of TNP in actual water samples.
Keywords:heterocyclic aromatic halide  fluorescent probe  2,4,6-trinitrophenol  theoretical calculations
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