Potential causal prophylactic antimalarial agents. Synthesis of quinoxaline,benzimidazole, and alkoxybenzene derivatives containing a novoldiamine moiety

Several quinoxaline, benzimidazole, and alkoxybenzene derivatives containing the novoldiamine function, either as a side chain or incorporated as a ring constituent, were synthesized as potential causal prophylactic antimalarial agents. 1-(5-Dimethylamino-2-pentyl)-5-methoxy-benzimidazole ( 2a ) was shown to have the desired prophylactic activity in the preliminary sporozoitc-indueed Plasmodium gallinaceum test.