| 一锅法合成芳(杂环)胺亚甲基双膦酸四乙酯 |
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| 引用本文： | 张宝华,史兰香. 一锅法合成芳(杂环)胺亚甲基双膦酸四乙酯[J]. 应用化学, 2020, 37(8): 877-882. DOI: 10.11944/j.issn.1000-0518.2020.08.200056 |
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| 作者姓名： | 张宝华 史兰香 |
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| 作者单位： | 石家庄学院化工学院 石家庄 050035 |
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| 基金项目： | 河北省科技支撑项目(18271404D)资助 |
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| 摘 要： | 以I2为催化剂,原甲酸三乙酯、芳(杂环)胺和亚磷酸二乙酯为原料,室温无溶剂条件下,一锅合成了系列芳(杂环)胺亚甲基双膦酸四乙酯,收率96%~99%。 当I2物质的量分数为5%时,产物收率最高。 本方法底物适用范围广,操作简单。 I2作为催化剂,安全高效。
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| 关 键 词： | 芳(杂环)胺亚甲基双膦酸四乙酯 I2 一锅法合成 无溶剂 |
| 收稿时间： | 2020-02-28 |
One-Pot Synthesis of Aryl/Heteroaryl Aminomethylene Bisphosphonates |
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| ZHANG Baohua,SHI Lanxiang. One-Pot Synthesis of Aryl/Heteroaryl Aminomethylene Bisphosphonates[J]. Chinese Journal of Applied Chemistry, 2020, 37(8): 877-882. DOI: 10.11944/j.issn.1000-0518.2020.08.200056 |
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| Authors: | ZHANG Baohua SHI Lanxiang |
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| Affiliation: | College of Chemical Engineering,Shijiazhuang University,Shijiazhaung,Hebei 050035,China |
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| Abstract: | A number of aryl/heteroaryl aminomethylene bisphosphonates were synthesized by one-pot reaction of diverse aryl/heteroaryl amines with diethyl phosphite and triethyl orthoformate in the presence of I2 under solvent free conditions. The product yields are 96%~99%. When the molar fraction of I2 is 5%, the product yield is the highest. The procedure is simple and the substrate scope is large. I2 is safe and very efficient as the catalyst. |
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| Keywords: | aryl/heteroaryl aminomethylene bisphosphonates I2 one-pot synthesis solvent free |
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