Enantioselective copper-catalyzed conjugate addition of dialkyl zinc to nitro-olefins |
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| Authors: | Alexakis Benhaim |
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| Affiliation: | Department of Organic Chemistry, University of Geneva, Switzerland. alexandre.alexakis@chiorg.unige.ch |
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| Abstract: | [reaction: see text]The copper-catalyzed asymmetric conjugate addition of dialkylzinc onto various nitro-olefins has been carried out with excellent results. An enantiomeric excess of up to 94% was obtained using 0.5% Cu(OTf)2 and 1% of chiral trivalent phosphorus ligand. |
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