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The asymmetric syntheses of the C-1 sidechains of zaragozic acid A and zaragozic acid C |
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| Authors: | Albert J. Robichaud Gregory D. Berger David A. Evans |
| Affiliation: | a Merck Research Laboratories, PO Box 2000, Rahway, New Jersey 07065 U.S.A. b Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138 U.S.A. |
| Abstract: | The asymmetric syntheses of the C-1 sidechains of zaragozic acid A and C are described. Aldol reaction defines the chirality at C-4′and C-5′in two independent routes. Multigram preparation as well as a route amenable to derivatization are highlights of these approaches. |
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