A formal total synthesis of the marine diterpenoid diisocyanoadociane |
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| Authors: | Fairweather Kelly A Mander Lewis N |
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| Institution: | Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia. |
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| Abstract: | Structure: see text] A formal total synthesis of diisocyanoadociane, a marine diterpenoid with potent antimalarial properties, has been completed. The synthesis begins with a phenanthrenoid precursor that is transformed into a pyrene-derived intermediate by means of an intramolecular Michael reaction. Nitrogen functionality is introduced via a double Curtius reaction. |
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