Synthesis of C8-C8/C2-C8-linked triazolo pyrrolobenzodiazepine dimers by employing ‘click’ chemistry and their DNA-binding affinity |
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| Authors: | Ahmed Kamal S. Prabhakar N. Shankaraiah Ch. Ratna Reddy P. Venkat Reddy |
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| Affiliation: | Chemical Biology Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A series of 1,2,3-triazole-containing pyrrolo[2,1-c][1,4]benzodiazepine dimers have been prepared efficiently by employing a ‘click’ chemistry protocol. This method involves 1,3-dipolar cycloaddition of terminal alkynes with organic azides using a Cu(I)-catalyst. Further, these molecules exhibited interesting DNA-binding affinity profiles. |
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| Keywords: | Pyrrolo[2,1-c][1,4]benzodiazepines 1,2,3-Triazoles DNA-binding affinity &lsquo Click&rsquo chemistry |
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