Offline LC-GC x GC in combination with rapid-scanning quadrupole mass spectrometry |
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Authors: | Sciarrone Danilo Tranchida Peter Quinto Costa Rosaria Donato Paola Ragonese Carla Dugo Paola Dugo Giovanni Mondello Luigi |
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Institution: | Dipartimento Farmaco-chimico, Facoltà di Farmacia, Università di Messina, Messina, Italy. |
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Abstract: | The present research is focused on the offline combination of normal-phase LC to double-oven GC x GC-quadrupole MS. Initially, a diesel sample was subjected to automated LC x GC in order to define the elution windows of four fractions, viz., saturated hydrocarbons, monocyclic aromatics, dicyclic aromatics, tri- + tetracyclic aromatics; each fraction was collected exploiting the LC system in a further analysis and subjected to large-volume-injection-GC x GC analysis using an apolar-polar column combination. The GC x GC operational conditions were tuned in relation to the specific separation requirements of each heart-cut. The main benefits of what can be defined as offline LC-GC x GC were: (i) the high first-dimension LC selectivity; (ii) the injection of high sample amounts in the GC x GC system, enabling the detection and quantification of a series of low-amount diesel constituents; (iii) improved GC x GC operational conditions for each heart-cut with respect to direct GC x GC. |
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