| A New Steroidal Saponin from Dioscorea deltoidea Wall var. orbiculata |
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| 引用本文： | PingSHEN XiKuiLIU 等. A New Steroidal Saponin from Dioscorea deltoidea Wall var. orbiculata[J]. 中国化学快报, 2002, 13(9): 851-854 |
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| 作者姓名： | PingSHEN XiKuiLIU 等 |
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| 作者单位： | [1]DepartmentofNaturalProductsChemistry,ShenyangPharmaceuticalUniversity,Shenyang110016 [2]KunmingInstituteofBotany,ChineseAcademyofSciences,Kunming650204 |
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| 摘 要： | Bioactivity-guided fractionation led to the isolation of a new steroidal saponin, orbiculatoside B, together with a pair of furostanol saponins, protobioside and methyl protobioside, from the fresh rhizomes of Dioscorea deltoidea Wall var. orbiculate. The new compound was identified to be isonarthogenin 3-O-α-L-thamnopyranosyl(1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranoside by various NMR techniques in combination with chemical methods. The three saponins showed strong activity against Pyricularia oryzae,and were cytotoxic to cancer cell line K562,HCT-15,A549, and A2780a in vitro.
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| 关 键 词： | 甾族皂角苷 皂草甙 薯蓣属植物 |
A New Steroidal Saponin from Dioscorea deltoidea Wall var.orbiculata |
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| PING SHEN,San Long WANG,Xi Kui LIU,Chong Ren YANG,Bing CAI,Xin Sheng YAO. A New Steroidal Saponin from Dioscorea deltoidea Wall var.orbiculata[J]. Chinese Chemical Letters, 2002, 13(9): 851-854 |
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| Authors: | PING SHEN San Long WANG Xi Kui LIU Chong Ren YANG Bing CAI Xin Sheng YAO |
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| Abstract: | Bioactivity-guided fractionation led to the isolation of a new steroidal saponin, orbiculatoside B, together with a pair of furostanol saponins, protobioside and methyl protobioside, from the fresh rhizomes of Dioscorea deltoidea Wall var. orbiculata. The new compound was identified to be isonarthogenin 3 O - a - L - rhamnopyranosyl (1 2) - [ a - L - rhamnopyranosyl - ( 1 4 ) ] - b - D - glucopyranoside by various NMR techniques in combination with chemical methods. The three saponins showed strong activity against Pyricularia oryzae, and were cytotoxic to cancer cell line K562, HCT-15, A549, and A2780a in vitro. |
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| Keywords: | Dioscorea deltoidea Wall var. Orbiculata orbiculatoside B Pyricularia oryzae cytotoxic. |
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