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Polymer conjugates with potential biological activity based on new derivatives of 2-mercaptobenzoxazole-synthesis and characterization |
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| Authors: | Rǎdiţa Aparaschivei Valeriu Şunel Mihaela Holban Marcel Popa Jacques Desbrieres |
| Affiliation: | 1. Department of Organic Chemistry, Faculty of Chemistry, “Al.I.Cuza” University, 700506, Iasi, Romania 2. Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of Iasi, 700050, Iasi, Romania 3. IPREM, Helioparc Pau Pyrenees, Pau and Adour Countries University (UPPA), 64053, PAU cedex 9, France |
| Abstract: | New potentially biologically active compounds derived from 2-mercapto-benzoxazole were synthesized and coupled on polymeric support of poly (maleic anhydride-alt-vinyl acetate) for the preparation of polymer-drug conjugates with controlled drug release. All compounds were characterized by elemental and spectroscopy (FT-IR, 1H-NMR) analysis. The toxicological tests recommend the products for further laboratory screening. |
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