Approaching exponential growth with a self-replicating peptide |
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Authors: | Issac Roy Chmielewski Jean |
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Affiliation: | Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA. |
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Abstract: | Self-replicating peptide systems hold great promise for a wide range of technological applications, as well as to address fundamental questions pertaining to the molecular origins of life. The development of self-replicating compounds capable of high efficiency, however, has remained elusive. Here we disclose a successful strategy whereby modulation of coiled-coil stability results in remarkable catalytic efficiency for self-replication. By shortening the peptide to the minimum length necessary for coiled-coil formation a highly efficient self-replicating system was obtained due to very low background reaction rates, bringing the efficiency close to naturally occurring enzymes. |
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