Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold |
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| Authors: | Eleni Dimitriou,Richard H. Jones,Robin G. Pritchard,Gavin J. Miller,Matthew O&#x Brien |
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| Affiliation: | 1. Lennard-Jones Laboratories, School of Chemical and Physical Sciences, Keele University, Keele, Borough of Newcastle-under-Lyme, Staffordshire, ST5 5BG, United Kingdom;2. The School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom |
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| Abstract: | Using a Tube-in-Tube device based on the amorphous Teflon AF-2400 fluoropolymer, a series of nitroarenes was hydrogenated to afford the corresponding aniline compounds. The system was then applied to the construction of a pyrrolobenzo[1,4]diazapene scaffold through a tandem hydrogenation-condensation-hydrogenation sequence. |
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| Keywords: | Gas-liquid flow Hydrogenation Pyrrolobenzodiazepine Reduction Cyclisation |
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