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Diastereospecific entry to pyrrolidinyldispirooxindole skeletons via three-component 1,3-dipolar cycloadditions |
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| Authors: | Yu-Lun Qian Bo Li Peng-Ju Xia Jing Wang Hao-Yue Xiang Hua Yang |
| Affiliation: | College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China |
| Abstract: | Practical and diastereospecific three-component 1,3-dipolar cycloaddition reactions of methyleneindolinones, isatins and diverse primary amino acids have been well established. A range of pyrrolidinyldispirooxindole scaffolds with wide structural diversity and complexity were obtained facilely in excellent yields under mild conditions, which hold promising applications in their further pharmacological studies. |
| Keywords: | 3,3′-Pyrrolidinyl-dispirooxindole isatin Azomethine ylides Primary amino acids Multicomponent 1,3-dipolar cycloaddition diastereoselectivity |
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