| 两种含氮类大豆苷元衍生物对人体红细胞的抗溶血作用（英文） |
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| 引用本文： | 刘会青,于渼璇,宋静磊,延玺,徐宁,郝海军.两种含氮类大豆苷元衍生物对人体红细胞的抗溶血作用（英文）[J].无机化学学报,2019(11):2168-2176. |
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| 作者姓名： | 刘会青 于渼璇 宋静磊 延玺 徐宁 郝海军 |
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| 作者单位： | 北京师范大学化学学院;北京大学第三医院风湿免疫科;北京化工大学化学学院有机化学系 |
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| 基金项目： | supported by Key Discipline Foundation of City of Beijing (Grant No.102-403101)~~ |
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| 摘 要： | 合成了2种含氮类大豆苷元衍生物,4,7-二((甘氨酸钠)羰基)甲氧基异黄酮(L1)和4′,7-二(肼羰基)甲氧基异黄酮(L2)并用元素分析、红外光谱和核磁共振氢谱对其进行了表征。研究了大豆苷元衍生物的抗氧化性能,评价了其对自由基、超氧阴离子自由基的吸附能力,以及对人体血红细胞抗氧化损伤的保护作用。实验结果表明,大豆苷元衍生物在生理pH条件下的抗氧化活性优于维生素C,特别是在清除羟自由基和抑制人血红细胞溶血方面,大豆苷元衍生物抗氧化能力表现更为突出。大豆苷元衍生物的羟自由基清除活性IC50值是维生素C的104倍。
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| 关 键 词： | 大豆苷元衍生物 抗氧化 人体血红细胞 |
Anti-hemolysis of Human Erythrocytes by Two Daidzein Derivatives Containing Nitrogen |
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| LIU Hui-Qing,YU Mei-Xuan,SONG Jing-Lei,YAN Xi,XU Ning,HAO Hai-Jun.Anti-hemolysis of Human Erythrocytes by Two Daidzein Derivatives Containing Nitrogen[J].Chinese Journal of Inorganic Chemistry,2019(11):2168-2176. |
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| Authors: | LIU Hui-Qing YU Mei-Xuan SONG Jing-Lei YAN Xi XU Ning HAO Hai-Jun |
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| Institution: | (College of Chemistry, Beijing Normal University, Beijing 100875, China;Department of Rheumatology and Immunology, Third Hospital of Peking University, Beijing 100083, China;Department of Organic Chemistry, College of Science, Beijing University of Chemical Technology, Beijing 100029, China) |
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| Abstract: | LIU Hui-Qing;YU Mei-Xuan;SONG Jing-Lei;YAN Xi;XU Ning;HAO Hai-Jun(College of Chemistry, Beijing Normal University, Beijing 100875, China;Department of Rheumatology and Immunology, Third Hospital of Peking University, Beijing 100083, China;Department of Organic Chemistry, College of Science, Beijing University of Chemical Technology, Beijing 100029, China) |
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| Keywords: | daidzein derivatives antioxidant human erythrocytes |
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