Synthesis of functionalized carboranes as potential anticancer and BNCT agents |
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| Authors: | Reddy Venkata Jaganmohan Roforth Matthew M Tan Chalet Reddy M Venkat Ram |
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| Institution: | Department of Chemistry, University of Minnesota at Duluth, Chem 233, 1039 University Drive, Duluth, Minnesota 55812, USA. |
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| Abstract: | Carboranyl aldehydes react with alpha,beta-unsaturated esters, ketones, and nitriles in the presence of DABCO to provide functionalized carboranyl alcohols in good yields. Acetates of these alcohols undergo a facile isomerization with a variety of nucleophiles and afford structurally interesting carboranes. Biological evaluation of these molecules exhibited impressive antiproliferative activity for brain and breast cancer cells. |
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