Preparation of a biphasic calcium phosphate from Ca(H2PO4)2·H2O AND CaCO3

Sintered hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) are the two most common bio-ceramics for bone substitute. Although their composition are analogous to the constituent of human hard tissue, but some disadvantages are always exist till now, such as they need a high temperature sintering process, and this would lose the functional groups for bioactivity and closed the micro- pores without any interconnections, that hamper the body fluid transportation and angiogenesis during regeneration. Furthermore, the sintered ceramics with block and fixed size is difficult to fit non-regular defect area. In this study, the mixtures of Ca(H₂PO₄)₂·H₂O and CaCO₃ were adjusted firstly, then distilled water were introduced in wet chemical method, and a biphasic ceramic of HAp/β-TCP will be obtained after drying and sintering, then the result product that prepared by wet chemical method will be the sample in this investigation. The physical properties of result powders were characterized by DTA/TG, XRD and SEM, respectively, the particle size of two bio-ceramics that after heat treatment were found under 5 μm in SEM examination. Powder type calcium phosphate ceramics with the Ca/P molar ratio of 1.67 can be as bone cement by mixing with polymeric binder, the fine particle product of the setting cement will possess micro-pores and macro-pores that after suitable heat treatment process, and this is good for fluid transportation and tissue regeneration.