"Cofactor"-controlled enantioselective catalysis |
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Authors: | Dydio Pawe? Rubay Christophe Gadzikwa Tendai Lutz Martin Reek Joost N H |
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Institution: | Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, The Netherlands. |
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Abstract: | We report an achiral bisphosphine rhodium complex equipped with a binding site for the recognition of chiral anion guests. Upon binding small chiral guests--cofactors--the rhodium complex becomes chiral and can thus be used for asymmetric catalysis. Screening of a library of cofactors revealed that the best cofactors lead to hydrogenation catalysts that form the products with high enantioselectivity (ee's up to 99%). Interestingly, a competition experiment shows that even in a mixture of 12 cofactors high ee is obtained, indicating that the complex based on the best cofactor dominates the catalysis. |
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