| A Convenient Synthesis of the Substituted 2,3—Diarylindole the Potent Selective COX—2 Inhibitors |
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| 引用本文： | WenHuiHU ZonRuGUO 等.A Convenient Synthesis of the Substituted 2,3—Diarylindole the Potent Selective COX—2 Inhibitors[J].中国化学快报,2002,13(4):296-298. |
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| 作者姓名： | WenHuiHU ZonRuGUO |
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| 作者单位： | [1]Departmentofsyntheticmedicinalchemistry,InstituteofMateriaMedica,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100050 [2]Departmentofsyntheticmedicinalchemistry,InstituteofMateriaMed |
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| 摘 要： | Phenyl sulfone-containing 2,3-diarylindole derivatives were designed and indentified to be selective COX-2 inhibitors. A convenient synthetic route was also developed for the synthesis of the novel inhibitors.
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| 关 键 词： | 2，3－二芳基吲哚 药效团 选择性 COX－2抑止剂 非甾族抗炎性药 |
A Convenient Synthesis of the Substituted 2,3-Diarylindole the Potent Selective COX-2 Inhibitors |
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| Wen Hui HU,Zon Ru GUO,Ai Ping BAI,Zhi Bin XU.A Convenient Synthesis of the Substituted 2,3-Diarylindole the Potent Selective COX-2 Inhibitors[J].Chinese Chemical Letters,2002,13(4):296-298. |
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| Authors: | Wen Hui HU Zon Ru GUO Ai Ping BAI Zhi Bin XU |
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| Abstract: | Phenyl sulfone-containing 2, 3-diarylindole derivatives were designed and identified to be selective COX-2 inhibitors. A convenient synthetic route was also developed for the synthesis of the novel inhibitors. |
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| Keywords: | Nonsteroidal anti-inflammatory drugs (NSAIDs) selective COX-2 inhibitors substituted 2 3-diarylindole pharmacophore |
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