Synthesis of 7a-substituted Hajos-Wiechert ketone analogues |
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| Authors: | Kennedy Jason W J Vietrich Sophia Weinmann Hilmar Brittain Dominic E A |
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| Affiliation: | Medicinal Chemistry, Bayer Schering Pharma AG, 13342 Berlin, Germany. |
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| Abstract: | A general and efficient route to 2-substituted 1,3-cyclopentadiones 3 has been developed. This operationally simple, two-step procedure is amenable to multigram scale preparations of these useful synthetic intermediates. These compounds are then transformed to previously unknown, higher analogues of the Hajos-Parrish-Eder-Sauer-Wiechert ketone (enone 1, R = Me) following an enantioselective Robinson annulation. |
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