Highly chemoselective and stereoselective synthesis of z-enol silanes |
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Authors: | Herath Ananda Montgomery John |
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Institution: | Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA. |
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Abstract: | Three-component nickel-catalyzed couplings of enals, alkynes, and silanes have been developed as a new entry to enol silanes. The enol silane and a trisubstituted alkene are both formed with >98:2 stereoselectivity, and the reaction tolerates a broad range of functionality including aldehydes, ketones, esters, free hydroxyls, and basic secondary amines. A mechanistic pathway involving the formation of a metallacycle that possesses an eta1 nickel O-enolate motif explains the high level of stereoselection. |
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