An approach to the tricyclic core of madangamines based upon a biogenetic scheme |
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| Authors: | Tong Han Min Martin Marie-Thérèse Chiaroni Angèle Bénéchie Michel Marazano Christian |
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| Institution: | Institut de Chimie des Substances Naturelles, CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, France. |
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| Abstract: | reaction: see text] A short synthesis of intermediates possessing the tricyclic core of natural madangamines, bioactive alkaloids found in marine sponges, is described. The key reaction entails the condensation of the sodium salt of diethylacetonedicarboxylate with a dihydropyridinium salt derivative. This new approach is modeled on a biogenetic proposal linking madangamines to ircinals, related alkaloids occurring in sponges of the same order. |
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