A new era for organic synthesis—highlights of the recent progress |
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Authors: | Yikang Wu Yu-Lin Wu |
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Institution: | (1) State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China |
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Abstract: | The major progress in organic synthesis since 2005 is briefly surveyed in two parts. The first part deals with some of the
most impressive advances in the synthetic methodology, which includes: (1) metal-mediated synthetic reactions, with an emphasis
on the olefin metathesis and gold-mediated reactions; (2) free radical-based organic synthesis; (3) synthetic transformations
performed in a “one-pot” manner involving either tandem reactions or multicomponent reactions; (4) asymmetric reactions catalyzed
by metal and organo-catalysts. The major advances in total synthesis of some complex natural products with significant biological
activities are presented in the second part, with detailed illustrations of ten selected molecules, including dragmacidin
F, abyssomicin C, 11-acetoxy-4-deoxyasbestinin D, pentacycloanammoxic acid, UCS1025A, (−)-merrilactone A, nigellamine A2, (+)-saxitoxin, and Tamiflu (an artificially designed natural product-like molecule). An array of complicated structures
of the natural products synthesized over the last two years is also listed to serve as a convenient lead to the original literature
for the prospective interested readers.
Translated from Progress in Chemistry, 2007, 19(1): 6–34 译自: 化学 进展] |
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Keywords: | organic synthesis metal-mediated synthetic reaction free radical reaction “ in one pot” reaction asymmetric reaction total synthesis of natural products |
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