Bioorganometallic fulvene-derived titanocene anti-cancer drugs |
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Authors: | Strohfeldt Katja Tacke Matthias |
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Affiliation: | School of Pharmacy, The University of Reading, PO Box 224, Whiteknights, Reading, Berkshire, UK. k.strohfeldt@reading.ac.uk |
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Abstract: | 6-Substituted fulvenes are interesting and easily accessible starting materials for the synthesis of novel substituted titanocenes via reductive dimerisation, carbolithiation or hydridolithiation reactions, which are followed by a transmetallation reaction with titanium tetrachloride in the latter two cases. Depending on the substitution pattern, these titanocenes prove to be bioorganometallic anti-cancer drugs, which have significant potential against advanced or metastatic renal-cell cancer. Patients bearing these stages of kidney cancer have a poor prognosis so far and therefore real progress in the area of metal-based anti-cancer drugs may come from this simple and effective synthetic approach. This tutorial review provides an insight into the synthesis of fulvene-derived titanocenes and their activity in preclinical experiments. |
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