Photoactivated 1,3-dipolar cycloaddition for the rapid preparation of F labelled radiotracers |
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| Authors: | David Thonon,Eve GoukensGeoffroy Kaisin,Jé rô me ParisJessica Flagothier,André Luxen |
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| Affiliation: | Cyclotron Research Center, Liege University, Sart-Tilman B.30, 4000 Liege, Belgium |
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| Abstract: | An 18F-labelled 2,5-diaryl tetrazole reagent has been prepared and reacted with substituted alkene dipolarophiles through a photoactivated 1,3-dipolar cycloaddition reaction. The radiobioconjugation reaction furnished the desired product in 5 min with radiochemical conversions of 85-95% at room temperature. Remarkably, for the activated dipolarophiles, these results were obtained in highly dilute solutions (10-100 μM). |
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| Keywords: | Photoclick chemistry Fluorine-18 2,5-Diaryl tetrazole Radiolabelling Radiopharmaceutical |
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