Synthesis, complexation studies and biological activity of some novel mono and tricyclic cyclophane amides and cyclophane sulfonamides |
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| Authors: | Perumal Rajakumar Ramar Padmanabhan |
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| Institution: | a Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600025, India
b Research and Development Centre, Orchid Chemicals and Pharmaceuticals Ltd., Sozhanganallur, Chennai 600119, India |
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| Abstract: | A series of mono, tricyclic cyclophane tetraamides and cyclophane sulfonamides have been synthesized and characterized from spectral and XRD studies. All the cyclophane amides form charge transfer (CT) complex with TCNQ. The cyclophane amides show moderate to good anti-inflammatory activity. Some of them were active against Gram positive (Klebsiella pneumonia) and Gram negative (Escherichia coli and Staphylococcus aureus) human pathogens. |
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| Keywords: | Tricyclic amides Tricyclic sulfonamides Charge transfer complex TCNQ Anti-bacterial activity Anti-inflammatory activity |
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