Isocyanide-based multicomponent reactions: synthesis of 3,3-dicyano-N-alkyl-2-arylpropanamide derivatives |
| |
| Authors: | Ebrahim Soleimani Mohsen ZainaliSaadi Samadi |
| |
| Institution: | a Department of Chemistry, Razi University, Kermanshah 67149-67346, Iran
b Department of Chemistry, Shahid Beheshti University, Tehran 19396-4716, Iran |
| |
| Abstract: | A new isocyanide-based multicomponent reaction between an aromatic aldehyde, malononitrile, an isocyanide, and acetic acid efficiently provides 3,3-dicyano-N-alkyl-2-arylpropanamide derivatives in excellent yields in ethanol at 70 °C. This reaction led to the construction of two carbon-carbon bonds and one amide group in a single synthetic step. |
| |
| Keywords: | Isocyanide 3 3-Dicyano-N-alkyl-2-arylpropanamide Multi-component reactions Malononitrile |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
