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A facile synthesis of spiro macrocarbocycles via the cycloalumination reaction of cyclic alkynes and alkadiynes |
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| Authors: | Vladimir A. D&rsquo yakonov,Regina A. TuktarovaLeonard M. Khalilov,Usein M. Dzhemilev |
| Affiliation: | Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Prospekt Oktyabrya, Ufa 450075, Russia |
| Abstract: | Zirconium-catalyzed cycloalumination of cycloalkadiynes assisted by Et3Al, subsequent treatment of the in situ generated tricyclic dialuminum compounds with BrCH2OMe and finally cyclopropanation of the obtained dispiro cyclopropyl dimethylene macrocarbocycles with Et3Al-CH2I2 represents an efficient one-pot synthetic approach to prepare di- and tetraspiro cyclopropane-containing macrocarbocycles in very high yields. |
| Keywords: | Homogeneous catalysis Organoaluminum compounds Spiranes Cycloalumination Dzhemilev reaction Cyclic diynes Bis-cyclopropanes Zirconocene dichloride |
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