4-hydroxy-2-quinolones. 109. Alkylation of 4-substituted ethyl 2-oxo-1,2-dihydro-quinoline-3-carboxylates |
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| Authors: | I V Ukrainets L V Sidorenko O V Gorokhova N L Bereznyakova S V Shishkina |
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| Institution: | (1) National Pharmaceutical University, Kharkiv, 61002, Ukraine;(2) Institute for Scintillation Materials, Ukraine National Academy of Sciences, Kharkiv, 61001 |
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| Abstract: | The alkylation of the ethyl esters of 4-methyl, 4-chloro-, and 4-amino substituted 2-oxo-1,2-dihydroquinoline-3-carboxylic
acid by ethyl iodide in the system DMF/K2CO3 has been studied. Features of the structure of the starting compounds and their effect on the ratio of the N-and O-alkyl
products formed are discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1502–1507, October, 2006. |
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| Keywords: | 2-oxo-1 2-dihydroquinolines 1H-quinolin-2-ones alkylation X-ray structural analysis |
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