A study of competitive molecular interaction effects on imprinting of molecularly imprinted polymers |
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| Institution: | 1. Grupo de Polímeros, Centro de Investigacións Tecnolóxicas, Universidade da Coruña, Campus de Esteiro s/n, Ferrol 15403, Spain;2. Dpto Química Orgánica I, Escuela de Óptica, Universidad Complutense de Madrid, Arcos de Jalón n° 118, Madrid 28037, Spain;1. Department of Chemistry – BMC, Uppsala University, SE-751 23 Uppsala, Sweden;2. Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, SE-391 82 Kalmar, Sweden;1. Departamento de Ciências Naturais, Universidade Federal de São João del-Rei (UFSJ), Campus Dom Bosco, Praça Dom Helvécio 74, Fábricas, 36301-160, São João del-Rei, Minas Gerais, Brazil;2. Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas (UNIFAL-MG), Rua Gabriel Monteiro da Silva, 700, Centro, 37130-000, Alfenas, MG, Brazil;1. Dept of Analytical, Bioanalytical Sciences and Miniaturization (LSABM) − UMR CBI 8231 (CNRS-ESPCI), ESPCI, PSL Research University, 10 rue Vauquelin, 75 231 Paris Cedex 05, France;2. L’Oréal Research and Innovation, 1 avenue Eugène Schueller BP22, 93601 Aulnay sous Bois, France;3. Sorbonne Universités, UPMC, 4 Place Jussieu, 75005 Paris, France;1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China;2. Department of Microbiology, College of Basic Medicine, Central South University, Changsha, 410083, PR China |
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| Abstract: | The work herein reports on an approach to obtain molecularly imprinted polymers (MIPs) for Atmer 129, an antistatic added to polyolefins and a previously non imprinted template with intra molecular H-bonding capability. The template–monomer interactions occurring in pre- and post-polymerization media were analyzed by FTIR and ATR-FTIR, respectively. After the prepolymerization study, the synthesis conditions were discussed and suitable porogens and potential template:monomer stoichiometries were suggested. The imprinting efficiency and selectivity of MIPs were evaluated in batch assays by HPLC or UPLC and compared with thermal behavior and morphological characteristics checked by Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM). The best results were obtained for MIPs synthesized at 60 °C. A relation between imprinting effect and template shape recognition was suggested by selectivity studies. The major conclusion, which has been drawn from FTIR and DSC studies, is that independently of the H-bonding strength between Atmer 129 and monomer, the template started to crystallize out during the polymerization reaction, thus reducing the imprinting effect. |
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