用于间质液检测的微针阵列研究进展

间质液是疾病诊断生物标志物的重要来源。微针阵列作为一种微创技术进入皮下间质液可以避免接触血管和神经，使用时疼痛感较小，易被患者接受，在多种领域都有广泛的应用。使用微针阵列检测间质液可以为临床诊断提供更多信息，研发制备简单、稳定性强和功能多样的微针阵列逐渐成为研究热点。本文介绍了间质液中生物标志物检测对人体健康监测的重要意义，总结了用于间质液检测的微针阵列的分类以及微针阵列制备所使用材料，着重介绍了微针阵列在间质液中采样与检测应用，讨论了微针阵列在间质液检测中的发展前景以及面临的挑战。

AdvancesoftheMicroneedleArrayforInterstitialFluidDetection

Interstitial fluid is an important source of biomarkers for disease diagnosis. As a minimally invasive technique, microneedle array can avoid contact with blood vessels and nerves when entering subcutaneous interstitial fluid, resulting in less pain and easy acceptance by patients. It has been widely used in various fields. The use of microneedle arrays to detect interstitial fluid can provide more information for clinical diagnosis. The preparation process of microneedle arrays is relatively simple and has multiple functions and high stability. Therefore, microneedle arrays have gradually become a research hotspot. This paper not only introduces the important significance of detecting biomarkers in interstitial fluid for human health monitoring, but also summarizes the classification of microneedle arrays and the materials used in their preparation. Finally, this article focuses on the application of microneedle arrays in sampling and detection of interstitial fluid, and discusses the development prospects and challenges of microneedle arrays in interstitial fluid detection.