Thermal,spectral, and thermodynamic studies for evaluation of calf thymus DNA interaction activity of some copper(II) complexes |
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| Authors: | Mohan N Patel Bhupesh S Bhatt Promise A Dosi |
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| Institution: | (1) Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India |
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| Abstract: | The square-pyramidal copper(II) complexes with ciprofloxacin in the presence of bipyridine derivatives have been synthesized
and characterized using elemental analysis, magnetic moment measurement, thermal analysis (TG), IR, mass and reflectance spectra.
The thermal denaturation study has been used for evaluating calf thymus DNA interaction activity. Spectral and hydrodynamic
measurements have been used for validating the DNA interaction study. The thermodynamic profile was established for proper
understanding of DNA binding Gibbs free energy. |
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