Conserved Domains,Conserved Residues,and Surface Cavities of C-reactive Protein (CRP) |
| |
Authors: | Suggula Varun Kumar Roshini Kulampurathu Ravunny Chiranjib Chakraborty |
| |
Institution: | (1) Medical Biotechnology Division, School of Bio-Sciences and Technology, VIT University, Vellore, India; |
| |
Abstract: | C-reactive protein (CRP) is a highly conserved plasma protein belonging to pentraxins, a superfamily which has significant
proinflammatory role. Therefore, CRP can be a good target for drug discovery to prevent disease pathogenesis, especially cardioprotection
in acute myocardial infarction and neuroprotection in stroke. Hence, the knowledge of the structure of CRP is very important.
In this paper, we have demonstrated three-dimensional structure, conserved domains, and surface structure of human CRP with
the help of bioinformatics analysis. We have also depicted that evolutionary relationship of CRP exists among the different
species. Simultaneously, WebLogo has been generated to know the more conserved part of this medically important protein. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|