| 抗癌药物在日本蛇根草中的检测 |
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| 引用本文： | 王伟,陆杨,李礼,王敬,钱忠英,周根余,开国银.抗癌药物在日本蛇根草中的检测[J].上海师范大学学报(自然科学版),2009,38(1). |
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| 作者姓名： | 王伟 陆杨 李礼 王敬 钱忠英 周根余 开国银 |
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| 作者单位： | 上海师范大学,生命与环境科学学院,上海,200234 |
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| 基金项目： | Shanghai Science and Technology Committee Project，Shanghai Education Committee Foundation，浙江省自然科学基金，Foundation from Shanghai Normal University，Leading Academic Discipline Project of Shanghai Municipal Education Commission |
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| 摘 要： | 利用HPLC技术在日本蛇根草中检测到了抗癌药物喜树碱(CPT)和羟基喜树碱(HCPT),而这2种药物是当今世界应用比较广泛的抗癌药物.蛇根草是中国传统的中草药,检测到日本蛇根草中含有CPT和HCPT,为获得这2种抗癌药物提供了新的生药途径,同时也为利用基因工程手段提高蛇根草中CPT和HCPT含量奠定了基础.
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| 关 键 词： | 日本蛇根草 喜树碱 羟基喜树碱 |
Distribution of anticancer drug in Ophiorrhiza japonica |
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| WANG Wei,LU Yang,LI Li,WANG Jing,QIAN Zhong-ying,ZHOU Gen-yu,KAI Guo-yin.Distribution of anticancer drug in Ophiorrhiza japonica[J].Journal of Shanghai Normal University(Natural Sciences),2009,38(1). |
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| Authors: | WANG Wei LU Yang LI Li WANG Jing QIAN Zhong-ying ZHOU Gen-yu KAI Guo-yin |
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| Institution: | College of Life and Environment Sciences;Shanghai Normal University;Shanghai 200234;China |
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| Abstract: | The anticancer drug Camptothecin(CPT) and Hydroxycamptothecin(HCPT) were detected in Ophiorrhiza japonica by high-performance liquid chromatogram(HPLC).The discovery of CPT and HCPT in such a Chinese traditional herb might provide a new approach to produce CPT and HCPT,which also served as an alternative model experimental system for studying CPT biosynthesis and even improving CPT content by genetic engineering in the future. |
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| Keywords: | HPLC Ophiorrhiza japonica camptothcein Hydroxycamptothecin HPLC |
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