| Abstract: | l-Alkylaryl-2-sulfamoylimidazole-5-carboxamides IV, V and VI were prepared starting from methyl l-alkyl-aryl-2-mercaptoimidazole-5-carboxylates I, II and III. Many interesting reaction intermediates such as the l-alkylaryl-2-sulfamoylimidazole-5-carboxylic acids (XVII, XX and XXI) were isolated. The structures of all of the compounds were determined by ir and nmr spectroscopy. Diuretic acitivity tests were also carried out on these compounds. In addition, l-alkylarylimidazole-5-carboxamides XXVII, XXVIII and XXIX were also prepared and tested for biological activity. |
