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Synthesis of 2-alkoxy-6-aryl-5-cyano-4(3H)-pyrimidinones |
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| Authors: | Miguel A Prez Jos L Soto |
| Institution: | Miguel A. Pérez,José L. Soto |
| Abstract: | The reaction of methyl 3-aryl-2-cyano-3-methoxypropenoates 1 with cyanamide and sodium methoxide in methanol afforded after acid hydrolysis the methyl 3-(aminocarbonyl)amino]-3-aryl-2-cyanopropenoates 4 . By performing the reaction in higher boiling alcohols the 2-alkoxy-6-aryl-5-cyano-4(3H)-pyrimidinones 2 were obtained in good yields. |
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