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A one step synthesis of thiadiazolo[2,3-b]quinazoline derivatives |
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| Authors: | Ahmad S Shawali Abdou O Abdelhamid Hamdi M Hassaneen Abdelfattah Shetta |
| Abstract: | Diazotized anthranilic acid and its methyl ester react with substituted phenacyl thiocyanates 3 to give in both cases the corresponding thiadiazolo2,3-b]quinazolines 7a-e . A mechanism is proposed and it is substantiated by alternate synthesis of 7a from the hydrazidoyl chlorides 9a,b and potassium thiocyanate. |
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